From the beginning of time man has sought a way to extend life, reverse the aging process, and live forever. Thus far, nothing has been proven to stop aging but we may be getting close.
The most promising therapy in this regard is stem cell therapy which is very expensive at this point. However, if government allows us the freedom; stem cell therapy will become available and would be the fountain of youth. Until stem cell therapy becomes more practical, the next best thing now available is Human growth hormone (HGH or Somatotropin)which can produce increases in the levels of insulin-like growth hormone 1 (IGF-1).
There is a direct connection between the level of this hormone in a human’s body, and their age. If this hormone could be kept at the levels of youth, then would the aging process be slowed down, or even stopped altogether? It is a question that has spawned much controversy within the ranks of physicians, with many leading doctors on both sides of the issue. The majority of antagonists, I would venture to guess, have no clinical experience using neither HGH nor the GH releasers (Sermorelin, GHRP-2 and GHRP-6).
Effects of Human Growth Hormone Decline:
The decline in human growth hormone is directly tied to the bulging, wrinkling, saggy, flabby, tired creatures that we eventually morph into. Those of us who have naturally lower amounts of hormone age much faster than those of us with good genes. Those who exercise hard also maintain a higher GH level.
Potential Benefits of returning Human Growth Hormone levels to younger adult levels.
There are several ways to increase your Growth Hormone level. All of the ones taken by mouth are either completely bogus or close to it. A sure way to increase HGH is to inject it. No doubt this works but is very expensive and it’s difficult to find a doctor to help you with this. The doctors that will help, typically charge a lot of money and legal GH can be $18 to $36 per day for an effective dose. Besides, this method doesn’t improve your own ability to make HGH. At high enough doses it may even further decrease your own ability to make it.
Another way is to use GHRP-6. This is a simple, amino acid chain complex that stimulates the pituitary gland to make and release more Human Growth Hormone (HGH).
Consult with your provider regarding how much of each hormone is right you. Growth Hormone Releasing Peptide – GHRP-6 is a 28-amino-acid peptide that signals the human body to begin secreting Growth-Hormone (GH). Growth Hormone secreted by the body then causes the liver to secrete the highly anabolic hormone known as IGF-1. IGF-1 also causes muscle building and fat burning. Several studies have shown this.
In several studies done in both humans and rodents, it has been found that GHRP-6 causes a spike of Ghrelin. This causes the most rapid side effect experienced with GHRP-6, extreme hunger, which typically occurs within an hour of injection. You would think this should cause weight gain but this doesn’t seem to be the case. in fact, I’ve yet to hear a patient mention an increase in appetite with GHRP-6.
GHRP-6 helps with fat loss. This is probably due to the fact that GHRP-6 is also a Ghrelin antagonist. This means it works against Ghrelin. This is likely how GHRP-6 causes fat loss in spite of the increased appetite.
Growth hormone (GH) has also been known to enhance immune responses and stimulate the immune system, whether directly or through the insulin like growth factor-1 signaled secretion caused by GH. This immune enhancing effect occurs particularly in older people.
GHRP-6 causes stimulation of the anterior pituitary gland which ultimately causes an increase in GH release. Since GHRP-6 acts directly on the feedback loop which signals the inhibition of GH release. When natural GH secretion has been inhibited by long term synthetic use, GHRP-6 can be used to re-stimulate the natural production of GH. GHRP-6 affects the central nervous system, by protecting neurons. GHRP-6 has been reported to increase strength similar to the way Dihydrotestosterone and related steroids work.
Sermorelin is a growth hormone secretagogue, which means that it stimulates the pituitary gland to produce and secrete HGH. It is a form of GRF that contains only the first 29 amino acids. GRF that is produced by neurosecretory neurons in the brain contains 44 amino acids. Only the first 29 amino acids are responsible for stimulating pituitary production and secretion of HGH. Therefore, the chemical name for Sermorelin is GRH 1-29 NH 2 The NH 2 is included in the name so as to indicate the amino terminus of the molecule.
Sermorelin has highly specific receptors on pituitary somatotrophs. So it binds to the cells that produce and release HGH. Upon binding, Sermorelin acts through a cylicAMP second messenger system exactly the same as that used by naturally occurring growth hormone releasing hormone. Furthermore, it has an excellent safety profile. Its effects are regulated at the level of the pituitary gland by negative feedback and by release of somatostatin so there are less safety concerns such as those associated with HGH overdosing. Tissue exposure to HGH released by the pituitary influence of Sermorelin mimics normal physiology, By stimulating the pituitary it preserves more of the growth hormone neuroendocrine axis that fails with aging, Semorelin in a complex way, helps preserve not only youthful anatomy but also youthful physiology, it gives all of the benefits of HGH and more. And it’s off label use is not illegal.
Semorelin has advantages over direct HGH injections. One is that continued use of HGH injections can lead to a decrease in effect over time. This is more likely with large doses and once per day dosing. This is because injection of HGH elevates blood levels of the hormone to unnaturally high values for several hours each day. Also, constant stimulation causes increased production of IGF-1 which also has more constant tissue exposure than under normal conditions. These factors causes target tissue receptors to “down regulate” in an attempt to prevent over stimulation by the unnatural exposure to HGH and IGF-1. Under physiological conditions, HGH is released from the pituitary gland in small bursts many times throughout the day. Under these conditions, down regulation does not occur since the tissues receptors get time to “rest” between each burst of GH. In contrast to HGH, there is no loss of potency with Sermorelin because its action on the pituitary gland is regulated by feedback through somatostatin. This causes HGH to be released from the pituitary in small amounts mimicking Mother Nature.
Another big advantage of semorelin is that it causes the pituitary gland to up-regulate. This stimulates the gland to rejuvenate.
There are many reports in peer-reviewed medical and scientific literature showing that GRF/Sermorelin also has a direct effect on the brain to promote non-REM slow wave sleep.
A combination of semorelin and GHRP-6 is available through the clinic for $50-$500 per month, depending on the dose needed. We would be monitoring your levels along the way to make sure it is increasing your IGF1.
MORE IS NOT BETTER. The goal of HGH therapy is to mimic younger levels. Bigger doses aren’t helpful and can be harmful. This is less likely with semorelin and GHRP-6.
WATCH FOR SIDE EFFECTS: regarding actual HGH injections, the side effects (water retention, sore muscles, and numbness in the hands) are related to doses that are too high. Prolonged high levels of HGH can cause serious side effects. This occurs in adults who have an HGH producing tumor of the pituitary. It is called acromegaly, characterized by over growth of the brow ridge, jaw, nose, ears, hands and feet. Soft tissue swelling of the hands and feet is often an early symptom, with patients noticing a change in ring or shoe size.
EXERCISE: Studies have shown that HGH replacement therapy is more effective for people who exercise regularly; especially short bursts of intense exertion (anaerobic exercise).
MULTIPLE VITAMINS: At Innovative Medicine we have very potent formulas; unavailable anywhere else.
SLEEP: Sleep is important to your health. Several anti-aging hormones are produced at higher levels during sleep than during the day. Semorelin an GH itself can improve sleep. If you are still having trouble with insomnia, melatonin can be dosed up to 20 m.g. Women usually get dramatic improvement with 100 to 400 m.g. of progesterone taken by mouth at bedtime. But if natural methods don’t work, I would rather prescribe a drug than have you toss and turn all night.
WATCH YOUR WEIGHT: HGH replacement therapy is not a diet program. Although it does tend to build muscle and reduce fat, many users find that they have an increased appetite.
SKIN AND SUN: Getting enough sun is very good for your health. Baking all day or getting burnt causes accelerated skin aging and the burning predisposes you to skin cancer.
DON’T SMOKE: It is a dirty, expensive habit and an extreme health risk. Chantix works very well for most smokers.
Some scientific studies display that HGH has little or no affect on athletes. One early study done in 1988 tested eight athletes for six weeks and showed that body fat decreased by a significant amount, however, muscle levels were not tested. In 1992, a major study of athlete’s performance done on 18 young men at the Washington University School of Medicine. Each man went through 12 weeks of resistance training. Muscles were measured at the end of the test, and all of the men had muscle gains. However, there were no differences in gained muscle size between the group who received the growth hormone, and the group who received the placebo. In 1995, another test on growth hormone was done. This time the strength of men was tested, on an older group of men, averaging 67 years of age. The same results occurred with the older men; there were gains in muscle size and strength, but the group that actually received HGH did not have any better gains than those who did not use the HGH.
Another study of 18 healthy men with ages ranging from 65-82 years went through 14 weeks of weight training before receiving HGH or a placebo. The group that received human growth hormone saw significant increases in lean body mass, and a loss of fat. However, this did not translate into better performance. The two groups’ overall muscle size gains were the same. Even though the muscular gains were the same, the significantly greater decrease in fat by the group that used HGH could be seen as a great benefit of the hormone for many people.
Although there is limited data on the use of growth hormone in athletes, there have been a lot of studies done on the elderly. The first scientific study on growth hormone in the elderly came out in 1990. Published by Dr. Rudman in the New England Journal of Medicine, the report showed the first findings of beneficial use of HGH in the elderly. The results of the effects of growth hormone on 12 elderly men, healthy in every way except a low level of IGF-1, were recorded. After receiving growth hormone for 6 months, the men had a 9% increase in muscle mass, a 14% decrease in fat, and a thickening of the skin.
The most influential part of this report on growth hormone was Rudman’s statement on the results of the test in which he wrote, “The effects of six months of human growth hormone on lean body mass and adipose-tissue mass were equivalent in magnitude to the changes incurred during 10 to 20 years of aging.” Dr. Rudman was effectively claiming that human growth hormone reversed the aging process. This report and Rudman’s statement effectively set off the growth hormone explosion. All types of people began to pursue the use of this hormone in order to increase performance or decrease the effects of aging.
There is a claim that HGH is a cause of diabetes. This is countered by two medical studies that state just the opposite, that in fact IGF-1 could be a replacement for insulin. If there is a connection between HGH therapy and diabetes it may have something to do with higher doses of HGH and once daily dosing. This is another argument for the use of semorelin and or GHRP-6.
Another benefit of the releasers over injecting HGH directly is cost. HGH may cost $1,000 per month. For similar results the releasers cost half as much from most sources. But in our clinic the cost is closer to 1/4 of the cost of HGH for the average person.
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